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Below, we exhibit that conolidine, a pure analgesic alkaloid used in conventional Chinese drugs, targets ACKR3, thus offering supplemental proof of the correlation involving ACKR3 and discomfort modulation and opening choice therapeutic avenues to the treatment of Continual soreness.It may also be legally bought to all athletes. Its formulation inc
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These success, along with a past report demonstrating that a small-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like behavior in mice,2 help the strategy of targeting ACKR3 as a unique approach to modulate the opioid procedure, which could open up new therapeutic avenues for opioid-associated Problems.These outcomes propose that conolidine is